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[Comment] Spironolactone for resistant hypertension—hard to resist?

Resistant hypertension is characterised by failure to achieve a blood pressure of less than 140/90 mm Hg while on maximum tolerated doses of three different classes of antihypertensive drugs, including a diuretic appropriate for kidney function.1 While often ascribed to medication non-adherence,2 true resistant cases of hypertension are linked to non-adherence to lifestyle modifications to control blood pressure, including low sodium diet, reduced alcohol ingestion, and weight reduction.3