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[Comment] Statin-associated muscle symptoms: beware of the nocebo effect

Patient-reported statin intolerance, predominantly due to statin-associated muscle symptoms (SAMS), is a common and difficult-to-manage condition affecting millions of patients worldwide.1 Different expert panels have proposed various definitions and classifications for statin intolerance.2,3 However, the development of SAMS does not necessarily signify statin intolerance since statin therapy might not always be pharmacologically involved. Moreover, some patients with SAMS might be able to tolerate a lower dose than the dose that leads to SAMS, longer dose intervals, or an alternative statin.