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[Comment] Tenofovir alafenamide for HIV infection: is less more?

Since the late 1980s, progressive development of antiretroviral drugs has revolutionised care for people with HIV infection. Early generation antiretrovirals saved the lives of patients dying from AIDS, in exchange for a high pill burden and substantial morbidity. However, such treatment was susceptible to treatment failure, especially before the introduction of combination antiretroviral therapy in the mid-1990s, but also later because of poor tolerability and adherence challenges. More recently, antiretroviral drug development has evolved towards drugs that are easier to take, resulting in improved adherence and clinical benefits.