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[Comment] Thresholds for safer alcohol use might need lowering

Guidelines for levels of alcohol use that pose a low risk to drinkers’ health are provided by many countries, usually based on meta-analyses of epidemiological studies.1–3 However, to devise such guidelines is challenging because alcohol is linked to poor health in various and complex ways. Injury, suicide, and assault, for example, are associated with drinking to intoxication, whereas regular alcohol consumption increases the risks of liver cirrhosis, gastrointestinal diseases, cardiovascular disease, dementia, and some types of cancer.