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[Comment] Treating giant-cell arteritis: is IL-6 the cytokine to target?

Giant-cell arteritis is a granulomatous vasculitis affecting medium-and-large-sized arteries responsible for cranial symptoms (eg, headaches, jaw claudication, and visual disturbance), polymyalgia rheumatica, and constitutional manifestations.1 In this population of patients older than 50 years, a still unknown initial trigger activates dendritic cells that will then attract T lymphocytes into the vessel wall.2 T-helper-1 and T-helper-17 CD4 T cells secrete cytokines, specifically interferon-γ and interleukin-17, which stimulate monocyte and macrophage recruitment.