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[Comment] Troponin assays: developing indications

Cardiac troponin assays were introduced into clinical practice in 1995 for the diagnosis of acute myocardial infarction. Originally, this assay could not help to reliably rule out myocardial infarction until about 12 h after symptom onset. Consequently, there has been a drive to develop more sensitive and reliable troponin assays that would facilitate an earlier exclusion of myocardial infarction, ideally in the emergency department.1–3