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[Comment] Volume expansion and contrast-induced acute kidney injury

There is an ever-increasing population at risk of being exposed to intravascular iodinated contrast because of the increasingly popular practice of imaging techniques in medicine and surgery. Despite efforts to improve the safety of these agents, there has been no fundamental improvement in contrast product development since the introduction of iso-osmolar contrast more than 20 years ago.1–3 Thus, clinicians have focused on strategies to decrease the risk of contrast-induced acute kidney injury by limiting contrast volume, giving adjuvant agents, and providing supportive care once the renal damage has occurred.