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[Comment] Whole brain radiotherapy in patients with NSCLC and brain metastases

Radiation oncologists are often challenged because of the paucity of randomised trials supporting their clinical practice. In terms of brain metastases treatment, it should be emphasised that there have been five randomised trials assessing whole brain radiotherapy (WBRT): four studies1–4 assessing stereotactic radiotherapy with or without WBRT for patients with four or less brain metastases, and the present trial by Paula Mulvenna and colleagues5 in The Lancet assessing optimum supportive care with or without WBRT in a much poorer prognostic population of patients with non-small-cell lung cancer (NSCLC).