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[Comment] Zika and histopathology in first trimester infections

The Zika virus epidemic that started in Brazil has led to thousands of cases of devastating neuropathology and miscarriage, stillbirth, and neonatal death. Although the US Centers for Disease Control and Prevention has concluded that Zika virus causes microcephaly and other fetal brain defects,1 demonstration of Zika virus in tissues is sparse. In The Lancet, Roosecelis Brasil Martines and colleagues’ case series2 documents Zika viral infection and pathology in three autopsy cases and two spontaneous abortions and is the first study we are aware of linking Zika virus to congenital malformations.