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[Correspondence] Bipolar disorder: defining symptoms and comorbidities

I enjoyed the comprehensive and thoughtful Lancet Seminar on bipolar disorder by Iria Grande and colleagues (April 9, p 1561).1 However, an historical correction concerning some statements on bipolar depression is necessary. The authors state that the symptomatic differences between unipolar and bipolar depression were first described in the 1950s by German psychiatrist Karl Leonhard and later validated in the 1960s by Jules Angst, Carlo Perris, and George Winokur. This statement is not correct.