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[Correspondence] Blood pressure and cardiovascular outcomes: a closer look – Authors’ reply

Michael Doumas and colleagues draw attention to blood pressure variability, which has been shown to be associated with adverse cardiovascular events, independently of mean blood pressure.1 Appropriate analysis of the prognostic value of visit-to-visit variability of blood pressure requires a variability measurement period (with several blood pressure values), and a subsequent outcome assessment period, as events might affect variability. The CLARIFY registry included a yearly blood pressure measure and therefore did not lend itself to a study of variability.