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[Correspondence] Ceftolozane-tazobactam versus levofloxacin in urinary tract infection

Florian Wagenlehner and colleagues1 compared ceftolozane-tazobactam with levofloxacin for the treatment of complicated urinary-tract infections. We are concerned about the fact that the intravenous dose of levofloxacin for the 7-day study period was tailored to a measured baseline creatinine clearance, which is very time-consuming and might be hampered by errors in the urine collection. If indeed an estimation of the creatinine clearance using the Cockroft-Gault formula was done, this seems to be the least appropriate calculation.