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[Correspondence] Could clinical symptoms be a predictor of complications in Zika virus infection? – Authors’ reply

The Zika virus epidemic in the Americas has been quickly followed by multiple attempts to quantify the association between the infection in pregnant women and microcephaly. It has become difficult to gain a coherent picture from estimates that are often based on different measures, in different populations, and with different case definitions. Understanding the mechanisms that might explain apparent discrepancies is essential to strengthening the risk assessment of Zika virus. Therefore, the Correspondence by André Ricardo Ribas Freitas and colleagues is particularly timely.