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[Correspondence] Could clinical symptoms be a predictor of complications in Zika virus infection?

Compelling evidence of the relation between Zika virus and microcephaly has been emerging in the scientific literature, although the risk in infected pregnant women remains largely unknown. Using retrospective data from routine ultrasonography and clinical examination at birth, Simon Cauchemez and colleagues (May 21, p2125)1 estimated the risk of microcephaly in newborn babies of infected pregnant women at 1% in French Polynesia. Their results differ from those reported in a prospective cohort of 88 pregnant women in Rio de Janeiro presenting with a rash during pregnancy, of whom 72 had Zika virus infection confirmed by RT-PCR.