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[Correspondence] Could upright posture be harmful in the early stages of stroke?

Findings from the AVERT trial (July 4, p 46)1 have effectively slain a long cherished theory of stroke unit enthusiasts, that the sooner mobilisation and active rehabilitation begin after stroke, the better. In fact, evidence of a small, but significant, harmful effect of early mobilisation was found. After adjusting for age and stroke severity, and applying the prespecified cutoff for favourable outcome on the modified Rankin scale, we estimate that one in 13 patients (95% CI 8–40) had worse outcome with early mobilisation than with standard treatment.