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[Correspondence] Did Cro-Magnon 1 have neurofibromatosis type 2?

In their Correspondence to The Lancet (March 31, p1259),1 Philippe Charlier and colleagues infer that the Cro-Magnon 1 skull (Les Eyzies, France) had neurofibromatosis type 1 (NF1). Their diagnosis was based on a micro-CT scan examination and three-dimensional reconstruction of the skull, which permitted a detailed analysis of the cranial fossil remains, including, in particular, the exact bone aspect of a round polycyclic osteolytic lesion on the right frontal bone (attributed to a progressive bone erosion secondary to a subcutaneous schwannoma) and the aspect and size of the cranial nerve foramina (showing “asymmetry of the size of the internal auditory meatus” secondary to an acoustic schwannoma without ad-ditional foramina anomalies).

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