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[Correspondence] Endpoints in diabetes cardiovascular outcome trials

Standardised Medical Dictionary for Regulatory Activities (MedDRA) queries (SMQs)1 and Customised MedDRA queries (CMQs) are routinely used to identify safety signals in clinical trials, including cardiovascular outcome trials. The three-component major adverse cardiac events (MACE) endpoint, often used to assess cardiovascular safety, includes a composite of cardiovascular death, non-fatal myocardial infarction, and non-fatal stroke.2,3 Hospital admission for heart failure is another cardiovascular endpoint of interest.