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[Correspondence] Exposure to lead in petrol and increased incidence of dementia – Authors’ reply

We appreciate the comments by Esme Fuller-Thomson and Sydney A Jopling, and Mark A S Laidlaw and colleagues on our cohort study,1 in which we investigated the association between living close to busy roadways and the incidence of dementia, Parkinson’s disease, and multiple sclerosis in Ontario, Canada. Both letters hypothesised that past exposure to leaded petrol might explain, at least partly, our observed association between living near roadways and higher incidence of dementia. Their proposition is an important reminder of the potentially long-lasting negative effects of many environmental factors on human health, even decades after exposures are dramatically reduced.