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[Correspondence] Increasing value and reducing waste in biomedical research

The challenges to biomedical research posed by the 2014 Lancet Series “Research: increasing value, reducing waste”, and renewed by David Moher and colleagues1 (April 9, p 1573), are daunting and rigorous. The recommendations are costly, and so the efficiencies need to outweigh them. Here, I wish to comment on three of the issues: the goal, the costs, and the causes of inefficiency, particularly in publication.