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[Correspondence] Intensive blood pressure lowering – Authors’ reply

Yuki Sonoda and colleagues raise two issues about our meta-analysis1 of randomised controlled trials that compared more versus less intensive blood pressure targets. First, the possibility that trials with major vascular events as a primary endpoint are different from trials in which major vascular events were not primary endpoints. Second, along with Mattias Brunström and Bo Carlberg,2 Sonoda and colleagues note the variety of patient populations included in our systematic review. We believe that the ability to compare and contrast treatment effects across different patient populations is a strength of systematic reviews.