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[Correspondence] Intensive blood pressure lowering

Xinfang Xie and colleagues (Jan 30, p 435)1 report that intensive blood pressure lowering provided greater vascular protection than standard regimens, especially in high-risk individuals. However, we are concerned about whether the incidence of vascular events was a primary endpoint or not in the studies included in their meta-analysis. As stated in the accompanying Comment by Mattias Brunström and Bo Carlberg,2 this meta-analysis included trials with a wide range of patient populations, and wide variations must have been observed in the incidence of vascular events according to patient background.