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[Correspondence] Interpretation of results of pooled analysis of individual patient data

We read with interest the meta-analysis by Stuart J Head and colleagues1 of individual patient data from randomised trials comparing percutaneous coronary intervention (PCI) with coronary artery bypass grafting (CABG) in patients with multivessel or left main disease. The authors found variation in outcomes according to the anatomical complexity of coronary artery disease, as gauged by the Synergy between PCI with Taxus and Cardiac Surgery (SYNTAX) score,2 but reported negative tests for interaction between subgroups of patients in the low (<23), middle (23–32), and high (>32) SYNTAX score tertiles and hazard ratios of death.