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[Correspondence] Leonardo’s mistake: not evidence-based medicine?

Renowned as one of the most influential figures in many different fields, Leonardo da Vinci (1452–1519) was also a revolutionary anatomist. In his research on the human body and reproductive system, da Vinci devoted a series of drawings to conception and the fetus, in which the fetal membranes (chorion, amnion, and allantois) are represented for the first time.1 Additionally, when depicting coitus, da Vinci introduced two errors: a canal in the penis connected to the spinal cord, and a canal linking the uterus to the breasts (figure).