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[Correspondence] Lessons from the INTERVAL study – Authors’ reply

The INTERVAL study1 randomly assigned 45 263 whole-blood donors to different intervals between donations to assess the effect of varying the frequency of donation on donor health and blood supply. Reducing the inter-donation intervals used in the UK to those used in blood services in the USA or western Europe led to a substantial increase in the amount of blood collected over the 2-year study period. For instance, reducing the inter-donation interval from 12 weeks to 8 weeks in men led to an increase in blood supply of 33% (an average of 1·7 units per donor).