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[Correspondence] Measurement of cardiac troponin for exclusion of myocardial infarction

As appropriately highlighted by the accompanying Comment,1 the study by Anoop Shah and colleagues (Dec 19, 2015, p 2481)2 nicely complements previous efforts defining safe and effective strategies to rule out myocardial infarction.3,4 We would like to ask the authors to better help clinicians to put their findings into perspective by providing more details regarding two methodological limitations that could affect the clinical application of the single value strategy. First, only 1608 (42%) of 3799 patients had serial sampling of cardiac troponin.