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[Correspondence] Mitochondrial donation: from test tube to clinic

The first licences permitting mitochondrial donation were issued in late 2017 by the Human UK Fertilization and Embryo Authority (HFEA), the statutory authority charged with regulating human embryo research, representing a historic landmark in the quest to eradicate transmission of serious mitochondrial DNA (mtDNA) disease.1 We previously estimated2 the average number of births per year among women at risk for transmitting mtDNA disease to be 152 (95% CI 125–200) in the UK and 778 (636–944) in the USA; mitochondrial donation will have an immediate and direct effect on these births.