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[Correspondence] Mortality risk with dual antiplatelet therapy?

The dual antiplatelet therapy (DAPT) study1 identified a significant reduction in ischaemic cardiovascular events with prolonged thienopyridine use on a background of aspirin therapy. An unexpectedly high mortality rate was seen among patients treated with drug-eluting stents who were randomly allocated to receive continued thienopyridine compared with placebo (2·0% vs 1·5%, p=0·05). Because of the crucial role that these medications have in treatment of cardiovascular disease, these findings prompted appropriate attention.