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[Correspondence] Network meta-analysis of antidepressants

It might be naive to draw conclusions about the effectiveness of antidepressants from the meta-analysis of trials, published and some unpublished, by Andrea Cipriani and colleagues.1 The null hypothesis to disprove is that the effect of antidepressants, as a drug class, is no different from that of placebo. Less than half of antidepressants trials submitted to the US Food and Drug Administration (FDA) are positive;2,3 many more negative trials are not submitted.