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[Correspondence] Network meta-analysis of antidepressants

In their network meta-analysis of 21 antidepressant drugs for the acute treatment of major depressive disorder in adults (April 7, p 1357), Andrea Cipriani and colleagues1 show that there is a statistically significant difference between drug and placebo, much in agreement with the results of previous systematic reviews.2,3 The crucial question is whether this difference has any clinical relevance.