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[Correspondence] New poliovirus vaccine schedules

In their randomised controlled trial, Edwin J Asturias and colleagues (July 9, p 158)1 reported a robust humoral immune response after three doses of bivalent type 1 and 3 oral poliovirus vaccine (bOPV) combined with zero, one, or two doses of inactivated poliovirus vaccine (IPV), confirming that bOPV is highly immunogenic when administered either with or without IPV. In their study, 6-week-old full-term Latin American infants due for their first polio vaccinations were randomly assigned by permuted block randomisation to five schedules.

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