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[Correspondence] On evidence-based medicine – Authors’ reply

We thank Marjolein A van der Marck and colleagues, Feras Ali Mustafa, and Jan Matthys for their interest in our Review.1 We agree with van der Marck and colleagues that tackling multimorbidity is an enormous challenge for evidence-based practice that, so far, has not been met. Authors within the evidence-based medicine (EBM) community have, however, suggested initial strategies for those who write guidelines2 and for the broader scientific community,3 and have emphasised the need for approaches that are minimally disruptive to patients’ lives.