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[Correspondence] Oxygenation targets in acutely ill patients: still a matter of debate

Derek Chu and colleagues1 analysed 25 randomised trials in the Improving Oxygen Therapy in Acute-illness (IOTA) systematic review and meta-analysis to define the efficacy and safety of liberal versus conservative oxygen therapy in acutely ill adults. The authors concluded that supplemental oxygen might become unfavourable above a peripheral oxygen saturation (SpO2) range of 94–96% because the risk of death increases in a dose-dependent manner. Their findings imply that when too much oxygen is administered in acute illness, it can exacerbate the patient’s health problem.