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[Correspondence] Oxygenation targets in acutely ill patients: still a matter of debate

We read with concern Derek Chu and colleagues’ systematic review and meta-analysis (April 28, p 1693)1 of oxygen use in acutely ill adults. Their finding that liberal oxygen therapy increases mortality when compared with conservative administration of oxygen therapy is provocative. It could also be misleading and potentially harmful if applied to patients. Specifically, several important factors should be considered before we reduce the concentration of oxygen given to patients.