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[Correspondence] Percutaneous coronary intervention for stable angina in ORBITA – Authors’ reply

We are delighted with the interest in ORBITA1 but saddened that so many conflate our trial report with the Comment2 written by others. As interventional cardiologists we were as disappointed as the correspondents with the prespecified primary endpoint analysis by use of prespecified statistical methods. We sympathise with our community’s shock and its instinct to invalidate the trial. Applying a positive spin could have smoothed the reception of the trial, but as authors we have a duty to preserve scientific integrity.