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[Correspondence] Pitfalls of the healthy vaccinee effect – Authors’ reply

In our Article,1 we presented findings from a case-control study that showed a protective effect of a meningococcal vaccine against gonorrhoea infection. In their Correspondence, Salaheddin Mahmud and Christiaan Righolt argue that the correct method to determine vaccine efficacy is a randomised controlled trial (RCT) and that our use of chlamydia as a control is problematic. We would like to clarify the points raised in their letter.