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[Correspondence] Predicting tuberculosis risk – Authors’ reply

Sandra V Kik and colleagues question the potential value of our RNA signature of tuberculosis risk for targeted intervention on a population basis.1 They point out that the positive predictive value (PPV) of the RNA signature depends on the rate of progression to active tuberculosis disease; prognostic utility would therefore be greatest in settings of high tuberculosis incidence. The Foundation for Innovative New Diagnostics and the New Diagnostics Working Group of the Stop TB Partnership have drafted an intervention target product profile (iTPP) for a new prognostic test for tuberculosis risk.