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[Correspondence] Preventing delirium: beyond dexmedetomidine – Authors’ reply

We thank Sinziana Avramescu and colleagues for their comments regarding the underlying mechanism of dexmedetomidine to reduce delirium in elderly patients in the intensive care unit after surgery. We agree that the reduction of delirium incidence seen after treatment with low-dose dexmedetomidine infusion might occur because of the drug’s neuroprotective effects, which have been well documented previously.1 In our previous study,2 these neuroprotective effects were shown to be mediated through α2A adrenoceptors.