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[Correspondence] Remediating “Lessons from the controversy over statins”

Richard Horton’s Offline Comment1 (Sept 10, p 1040) refers to the paper we published in The BMJ2 as “disputed research and tendentious opinions about statin use among people at low risk of cardiovascular disease”, but fails to report that the primary analysis and conclusion in our article have not been disputed. Rather, the conclusion of the 2012 Cholesterol Treatment Trialists (CTT) meta-analysis3 that “In individuals with 5-year risk of major vascular events lower than 10%, each 1 mmol/L reduction in LDL cholesterol produced an absolute reduction in major vascular events of about 11 per 1000 over 5 years” is what is disputed.