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[Correspondence] Renal denervation for resistant hypertension

The DENERHTN trial (May 16, p 1957)1 reported that renal denervation was associated with a baseline-adjusted difference of −5·9 mm Hg in daytime ambulatory systolic blood pressure after 6 months in favour of interventional treatment. Surprisingly, and in stark contrast with the results from the Symplicity HTN-2 and HTN-3 trials, the blood pressure response with ambulatory blood pressure measurements was as high as with office blood pressure measurements.1–3 Specifically, in the Symplicity HTN-2 trial, office blood pressure was reduced by 32/12 mm Hg and 24 h ambulatory blood pressure was reduced by only 11/7 mm Hg after 6 months with renal denervation, and in the Symplicity HTN-3 trial, systolic office blood pressure changed by 14·1 mm Hg and 24 h ambulatory systolic blood pressure by only 6·7 mm Hg after 6 months with renal denervation.