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[Correspondence] Risk thresholds for alcohol consumption – Authors’ reply

To define alcohol consumption thresholds associated with lowest risk for all-cause mortality and cardiovascular disease subtypes, we analysed individual-participant data from 599 912 current drinkers without previous cardiovascular disease.1 Among current drinkers, the threshold for lowest risk of all-cause mortality was about 100 g per week. For cardiovascular disease subtypes other than myocardial infarction, there were no clear risk-based thresholds below which lower alcohol consumption stopped being associated with lower disease risk.