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[Correspondence] Safety and efficacy of statins

We read with interest the Review by Rory Collins and colleagues1 about the efficacy and safety of statin therapy. The authors state that each mmol reduction of LDL cholesterol is associated with a decrease in major vascular events and mortality, both in primary and secondary prevention of heart attacks and strokes. However, the relationship between cholesterol and cardiovascular events seems to decrease with age. Review of previous large observational cohort studies has even shown a higher all-cause mortality when total cholesterol and LDL-cholesterol levels were in the lowest ranges, particularly with total cholesterol less than 5·5 mmol/L in people older than 80 years.