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[Correspondence] Stem cells in age-related macular degeneration and Stargardt’s macular dystrophy – Authors’ reply

We thank Janet Sunness and Guo-You Zhang and colleagues for their comments on our Article.1 Sunness asserts that transplantation of human embryonic stem cell-derived retinal pigment epithelium (hESC-RPE) into patients with advanced dry age-related macular degeneration and Stargardt’s disease needs to be tested. We report only visual improvements as noted during the course of a phase 1 safety trial. As mentioned in our Article,1 many potential explanations are available for these observations other than an actual functional improvement, including those suggested by Sunness.