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[Correspondence] The BLISTER study: possible overestimation of tetracycline efficacy – Authors’ reply

We thank Michael J Sladden and Peter E Hutchinson for their comments, but respectfully disagree that our study design1 favoured doxycycline. BLISTER was not an efficacy study of doxycycline versus prednisolone. We investigated whether a doxycycline-initiated pemphigoid treatment strategy could result in improved safety and acceptable effectiveness, when compared with starting with prednisolone. The doxycycline-initiated strategy was expected to be 25% less effective than prednisolone at 6 weeks.