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[Correspondence] The CONFIDeNT trial

The Article by Charles Knowles and colleagues (Oct 24, p 1640)1 reports outcomes that are different from those initially registered.2 The Article reports the single prespecified primary outcome but only seven of the ten prespecified secondary outcomes; one prespecified secondary outcome is solely reported in the appendix and two are not reported anywhere. Additionally, the Article reports three new secondary outcomes, which were not prespecified, without flagging them as such.