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[Correspondence] The promise of personalised medicine

Genomics are anticipated to have an important role in promoting population health by being used to target at-risk individuals. In 2015, Victor Dzau and colleagues1 proposed that identification of genomic variants in major complex diseases would lead to modulation of health-related behaviours, with a 10–50% reduction in disease incidence. Most studies in a Cochrane review,2 however, showed no evidence of incremental behavioural changes by patients after provision of genetic risk information alongside lifestyle interventions.

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