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[Correspondence] Treating sickle cell anaemia: the TWiTCH trial

The TWiTCH trial (Feb 13, p 661)1 is the first randomised trial comparing hydroxyurea with transfusions in children with sickle cell anaemia with abnormal high transcranial doppler (TCD) flow velocities. We congratulate the authors for this important work. Nevertheless, we have some concerns about their conclusion.