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As of January 2019, we will no longer be sending out the doctorportal email newsletter. The final issue of this newsletter will be distributed on 13 December 2018. Articles from this issue will be available to view online until 31 December 2018.

[Correspondence] Treating sickle cell anaemia: the TWiTCH trial

The TWiTCH trial (Feb 13, p 661)1 is the first randomised trial comparing hydroxyurea with transfusions in children with sickle cell anaemia with abnormal high transcranial doppler (TCD) flow velocities. We congratulate the authors for this important work. Nevertheless, we have some concerns about their conclusion.