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[Correspondence] Vaginal progesterone prophylaxis for preterm birth – Author’s reply

We thank Dimitrios Papoutsis and Angeliki Antonakou and John O’Brien for their comments on our OPPTIMUM trial.1 We are somewhat surprised that Papoutsis and Antonakou describe the editorial accompanying OPPTIMUM as expressing “scepticism”—that was not our interpretation.2 However, we agree that further subgroup analyses might be helpful.

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