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[Correspondence] Vaginal progesterone prophylaxis for preterm birth

In The Lancet, Jane Norman and colleagues (May 21, p 2106)1 reported the OPPTIMUM study, in which vaginal progesterone was not associated with a reduced risk of preterm birth or composite neonatal outcomes, and had no long-term benefit or harm on outcomes in children at age 2 years.2 These results are in contrast to the Cochrane Library meta-analysis reporting that progestogens reduced the incidence of preterm birth.3 Norman and colleagues commented that their findings suggest that the efficacy of progesterone in improving outcomes is either non-existent or weak.