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[Correspondence] White individuals’ risk of premature mortality in context

Meredith Shiels and colleagues’ (March 11, p 1043)1 analysis of adult premature mortality between 1999 and 2014 shows a disturbing increase among young and middle-aged white individuals, similar to other findings.2 Alarm is justified: increasing adult mortality is rare. For example, the reported 111 000 excess premature deaths in white individuals aged 25–49 years from 2000 to 2014 were unexpected and preventable (largely due to drug poisonings, suicide, and liver disease and cirrhosis).