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[Editorial] Systemic sclerosis: advances and prospects

Of all the rheumatological diseases, systemic sclerosis (scleroderma) has the highest case-specific mortality and substantial non-lethal complications. It is a rare multisystem autoimmune disease of the connective tissue, distinguished by prominent fibrosis and vasculopathy of the skin and internal organs. A Seminar by Christopher Denton and Dinesh Khanna is the first comprehensive clinical review on systemic sclerosis since a formal evidence-based management guideline in 2016 and the results of key trials of stem-cell therapy and immunosuppression were published.

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